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Specificity analyses also consistently indicated significant associations between GLP-1 RAs use and reduced risks in different composite adverse outcomes, further substantiating the robustness of our results (Figure S4)
It means there is not enough evidence to guarantee safety
The NICE ethnic BMI adjustment NICE guideline NG246 (2025) sets a lower obesity threshold of BMI 27.5 for people from South Asian, Chinese, Other Asian, Middle Eastern, Black African, and African-Caribbean backgrounds 3
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Around the same time, I think you remember that all of pharma was interested in obesity in the early 90s, everyone wanted to do diabetes as well as obesity, but they were separate teams and they all wanted to do small molecules, but it just happens to be so that the best idea we could find at that time was actually GLP-1, because we actually had clinical data relatively early that GLP-1 was a really good candidate as a treatment for diabetes because of the glucose sensitivity of the actions
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