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Obesity rates have almost tripled since 1975, which researchers say is due to a combination of factors, including: Increased access to energy-dense food coupled with reduced physical activity Sleep deprivation Circadian desynchronization Chronic stress A rise in the use of certain medications known to result in weight gain, including some anti-epileptic and psychotropic drugs Other genetic and environmental factors As a result, prescription drug companies have sought their own way to target the treatment of obesity

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This extended signaling allows for a steady, basal increase in growth hormone and IGF-1 levels without causing the aggressive spikes that disrupt natural endocrine rhythms

The trials were well-designed, the results compelling

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