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The only OTC weight loss pill approved by the FDA is Alli (orlistat), and studies have shown that its effective for obese patients as an adjunct to therapeutic lifestyle changes
George Kamel explains that as people lose weight, they also lose the underlying fat that helps plump and fill out the face, giving them a sunken look, and experience a decline in collagen and elastin
Most patients begin seeing changes by week 24
however, the trial was only powered to assess safety
doi: 10.7759/cureus.11703 67 DyerAHVahdatpourCSanfeliuATropeaD
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