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Cancer cell biology research examining IGF1R-driven proliferation often uses LR3 as a standard reagent precisely because the dose-response across a multi-day proliferation assay is more interpretable when the ligand is stable in the media

Severe events (1.4%) included cases requiring gynecological evaluation: one case of endometrial hyperplasia, two cases of ovarian cysts requiring imaging, and several cases of menorrhagia (excessive bleeding) requiring iron supplementation or hormonal intervention

Abstract The oxidizability of cysteine residues is exploited in redox chemistry and as a source of stabilizing disulfide bonds, but it also raises the possibility that these side chains will be oxidized when they should not be

It started as a gut compound, but the animal data set off the hype