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This timing aligns with the medication's mechanism: semaglutide immediately begins slowing gastric transit, which your stomach interprets as an unfamiliar sensation before adaptation occurs

However, she told the Today hosts that, of the three most common effectsnausea, diarrhea, and constipationshe suffered most from constipation

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This physiological approach means that some degree of hunger, particularly in response to genuine energy needs or specific circumstances, may still occur even when the medication is working effectively

This aggressive titration schedule may contribute to the higher side effect rates seen in early treatment weeks