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The mechanisms underlying IGF-1's tendon repair effects involve activation of the IGF-1 receptor on tenocytes and tendon stem cells, leading to enhanced extracellular matrix synthesis, improved cellular migration to injury sites, and optimized remodeling of repair tissue
10.1186/s12967-024-05182-y 69 IzuH.InouyeS.FujimotoM.ShiraishiK.NaitoK.NakaiA
Water retention particularly in the first week of use
While home treatments may work for small areas of scarring, older or more visible scars will often only respond to medical or cosmetic procedures
Common Symptoms of EDS Symptoms may include: Joint hypermobility (double-jointedness) Frequent joint sprains and injuries Joint instability and subluxations Recurrent dislocations Chronic neck and back pain Widespread musculoskeletal pain Tendon and ligament injuries Muscle spasms and myofascial pain Fatigue and exercise intolerance Headaches and migraines Temporomandibular joint (TMJ) dysfunction Poor proprioception and balance Sleep disturbances Easy bruising and soft tissue injuries Many patients experience symptoms that fluctuate over time and may worsen following injury, illness, stress, or increased physical activity
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