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In the UK, buying and injecting B12 yourself is strongly advised against
What Are Vitamin B12 Shots For Weight Loss
These are investigational agents used off-label through compounding pharmacies
If oral B12 replacement has been trialled in a person with metformin-associated B12 deficiency, I would suggest that a repeat measurement of B12 levels after 812 weeks is a good time to reassess whether absorption is adequate or whether a switch to intramuscular replacement is required
Initial signs of response typically appear by week 3-4, with meaningful results developing through weeks 5-8
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