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Appropriate control of the immune response is required to prevent either hyperresponsive or inadequate responses, which are harmful to the host body that may lead to immune-related diseases ( Cell signaling networks play a necessary function in the etiology of numerous diseases by stimulating cell survival, proliferation, and apoptosis (Jantan et al., 2021)

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AES (Supplementary Note 1) were synthesized by PCR amplification of the Kan R cassette of pKD4 using primers containing 50 bp identity arms (Supplementary Table 2)