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Importantly, NSAIDs should generally be avoided in cirrhosis or advanced liver disease due to increased risks of renal impairment, gastrointestinal bleeding, fluid retention, and hepatic decompensation, as advised by NICE guidance (NG50: Cirrhosis in over 16s)

That comparative angle is what makes consistent, accurately-measured stocks so important your concentration has to be trustworthy if you're benchmarking against a control

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doi:10.1016/j.jdermsci.2007.05.002 80

A 2024 metabolism study added another layer of complexity