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Experimental Physiology

Nrf2 is involved in not only the regulation of GSH synthesis and reduction via upgrading some enzymes and proteins (SLC7A11, GCLM, GCLC, GR) but also the activation of GSH-dependent antioxidant enzymes (GPX, GST) [200, 201]

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Complementary Ingredients for Skin Health While glutathione is a powerhouse on its own, it works best when supported by other nutrients

It also increases plasma BDNF levels, providing a measurable biomarker of its neurotrophic activity