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Predictions were made across observed dose ranges, and minimal effective doses were estimated based on both the upper bounds of 95% CIs and the predicted mean difference required to reach a clinically meaningful reduction

While the appetite suppressive effects of amylin and GLP-1 receptor agonists are known to involve direct actions in the brain 6,7,9,10,12,13,14 , uncovering the neuroanatomical site(s) of action and the physiological mechanisms that mediate the anorectic response remains an area of intense research focus

Specific abnormalities were observed for different classes of POPs

Study selection We developed eligibility criteria for inclusion in the literature based on the PICOS principles