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Generic liraglutide has been available since 2024 ( [68] ), and semaglutides US patent exclusivity is set to expire on March 20, 2026, which could further reshape the competitive landscape

The term had circulated in patient communities and across TikTok for years, but it reached a mass audience in 2024, when Oprah Winfrey devoted a primetime special, "Shame, Blame and the Weight Loss Revolution," to weight-loss medications and spoke candidly about how they quieted her own food noise

doi:10.1016/S2666-5247(23)00221-5

The primary known effectdelayed gastric emptyingalters the normal digestive rhythm, which may contribute to changes in bowel habits in some individuals

This increases reliance on independent verification or community reports