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This term is useful, because drugs that have a pKa higher than 7.2 may be sequestered to a slightly higher degree than one with a lower pKa

Intrinsic factor binds cobalamin only within the alkaline pH of the intestines

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They achieve this by regulating the differentiation of nave CD4 + T cells into specific T-helper (Th) subpopulations, such as Th1, Th2, and Th17, via the provision of co-stimulatory signals and the secretion of distinct cytokines (214, 269, 270)