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Effects diminish because the drug clears, not because the body becomes dependent on it
An integrated approach can reveal new drug combinations or guide personalized treatment strategies, ultimately bridging the gap between laboratory research and clinical application
Approved indications for GLP-1s: Cardiovascular disease Chronic kidney disease Obesity Sleep apnea Type 2 diabetes Metabolic dysfunction-associated steatohepatitis (MASH) Potential future indications: (indications with asterisks have already been investigated in randomized clinical trials) Substance use disorders (alcohol, tobacco) Alzheimers Parkinsons Cancer prevention Diabetes prevention* Diabetic retinopathy Heart failure* Osteoarthritis* Peripheral artery disease* Polycystic ovarian syndrome Psoriasis When I was at the ADAs 85th Scientific Sessions this year, what was quite apparent was just how quickly the field has progressed beyond GLP-1s
Among people paying over $1,000 per month, dissatisfaction spikes: Nearly 40% report being very dissatisfied, and fewer than 1 in 3 say they are very satisfied
This method is not FDA-approved and can be risky
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