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Deoxygenation of the SS RBCs reduced their Ca2+ pump Vmax, more so in reticulocyte- and discocyte-rich than in dense cell fractions, and decreased their cytoplasmic Ca2+ buffering
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Synthetic peptides, such as P1, derived from collagen, also enhance extracellular matrix (ECM) remodeling, thereby accelerating wound repair
BPC-157 promotes angiogenesis through the Egr-1/NAB2 regulatory loop, which simultaneously activates vessel growth (Egr-1) and provides an internal brake (NAB2) to prevent disorganized growth
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