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van de Leemkolk, F

Evidence summarized by Peptide Sciences notes that copper(II) ions can inhibit type 1 5--reductase activity by up to ~90% in vitro (half-maximal inhibition at ~0.12 g/mL Cu), with substantially less effect on type 2 suggesting follicle-localized DHT suppression without system-wide androgen blockade

Singh AV, Bhardwaj P, Laux P, Pradeep P, Busse M, Luch A, Hirose A, Osgood CJ, Stacey MW

Dupilumab treatment restores lesional and nonlesional skin barrier function in adults and adolescents with atopic dermatitis irrespective of the filaggrin genotype: results from an open-label, healthy-control-matched, phase 4 clinical study (BALISTAD)

This is why autoimmune gastritis B12 deficiency deserves more attention