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Published data from growth hormone axis studies demonstrates that this pulsatile delivery pattern more accurately mimics endogenous GHRH secretion rhythms compared to continuous infusion models

Khan et al., 2019) (Table 1)

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This might be because the limited time of LOsG treatment resulted in a conversion of a subset of -cells to -cells at early stage, and others had not started to change yet

In the intracellular side, a sharp kink located in the conserved Pro 6.47b -X-X-Gly 6.50b motif pivoted the intracellular tip of TM6 to move outwards by 19.3 (measured by C atom of K344 6.35b ), slightly higher than that seen with the GCGGCGRG s (17.7 ) 4