Workers exposed to plants containing parthenolide were thought to be susceptible to contact dermatitis, but current reports state that the drug is mutagenic in vivo and in vitro due to oxidative DNA damage or other possible mechanisms, raising concerns about the genotoxicity of the drug
Regulation of p53 by activated protein kinase C-delta during nitric oxide-induced dopaminergic cell death
1 Its considered the bodys master antioxidant because it protects cellular activity from within the cells, but it also regenerates other antioxidants and acts as a cofactor for many enzymes
Multiple reviews and meta-analyses show that berberine supplementation can modestly improve fasting glucose, HbA1c, and other cardiometabolic markers across diverse adult populations.64 65 While its effects are not dramatic, theyre repeatable and biologically plausible, which is why berberine is often discussed alongside diet and lifestyle strategies for metabolic risk
NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis