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UA treatment (200 M UA) alleviates oxidative stress and prevents dopamine neuron loss in 6-OHDA-induced rats by recovery of Akt and GSK3 [171]

Commodore-Mensah Y, Loustalot F, Himmelfarb CD, Desvigne-Nickens P, Sachdev V, Bibbins-Domingo K, Clauser SB, Cohen DJ, Egan BM, Fendrick AM, Ferdinand KC, Goodman C, Graham GN, Jaffe MG, Krumholz HM , Levy PD, Mays GP, McNellis R, Muntner P, Ogedegbe G, Milani RV, Polgreen LA, Reisman L, Sanchez EJ, Sperling LS, Wall HK, Whitten L, Wright JT, Wright JS, Fine LJ

(24) Preclinical animal models demonstrated that GLP-1 receptor agonists may help protect against fractures and reduce advanced glycation end-product (AGE) accumulation in diabetic subjects

This flexibility helps with microdosing protocols or slower-than-standard titration

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