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According to NICE guidance , arthritis management in the UK follows a stepwise approach: Non-pharmacological interventions : Exercise programmes, physiotherapy, weight management, and patient education Pharmacological treatments : For OA, topical NSAIDs as first-line (NICE NG226)

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According to Langan et al., there are a limited number of case studies where researchers have described cases of melanotan I use leading to changes in skin moles [19]