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Safety, Monitoring & Adjustments You should begin with baseline labs, including IGF-1 / GH axis 12 , complete blood count (CBC), metabolic panel (glucose, lipids), liver and kidney function, to detect any underlying issues

Avoid starting new patients on GLP-1 treatment until supply stabilizes

If retatrutide improves glycaemic control over time, this background risk may in fact be reduced rather than increased though this has not been specifically studied for retatrutide

In general, smaller, well-shaped pills are easier to swallow