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Activation of the GLP-1 receptor initiates a series of cascading reactions, which exert a hypoglycemic effect by stimulating insulin secretion from pancreatic -cells and inhibiting glucagon secretion from -cells, thereby reducing the stimulatory effect of glucagon on gluconeogenesis in the liver (Xia et al., 2024

This dual actionboth peripheral (at the stomach level) and central (in the brain)contributes to reduced caloric intake in many patients

analyzed patients initially treated with GLP-1 RAs or SGLT2i, subsequently adding the second agent to evaluate the effects of combination therapy compared to monotherapy and differencing across groups (113, 114)

PortionIQ aims to address the risk of nutrient gaps linked to reduced appetite, particularly protein intake, which becomes critical for preserving lean mass during weight loss