Current research indicates that semaglutide does not have a direct impact on thyroid hormone production or thyroid gland function
For example, rat TDSCs treated with IGF-1 (1, 10, and 100 ng/mL) for 28 days exhibited the increased expression of tendon-specific marker (SCX) and significantly decreased expression of chondrogenic and osteogenic marker (collagen type II) (Holladay et al., 2016)

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Discussion The studies investigating pharmacokinetics of semaglutide administered subcutaneously demonstrated T max values ranged from 30 h to 56 h in healthy subjects, and from 24 h to 77.8 h in diseased participants
Pairing this peptide with GHK-Cu can potentially create a recovery blend for accelerated tissue repair, collagen synthesis, and anti-aging