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Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent
ZMT (6 capsules nightly) Combines zinc, magnesium, ashwagandha, and other adaptogens to promote deep sleep, testosterone production, and cortisol regulation
Side effects are comparable, though AOD 9604 has more clinical data supporting its safety profile
Now, while injectable B12 is generally very safe, it is important to be aware of potential side effects
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