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These data demonstrate that high OxPhos signalling is associated with 5FU resistance and suggest that enhanced mitochondrial metabolism promotes treatment failure clinically
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One study of 30 patients on nasal glutathione dosed at either 300mg or 600mg daily in three divided doses vs placebo over a three month period found significant improvement in UPDRS scores in the treatment arms over placebo while other measures of toxicity such as cell counts, liver enzymes, creatinine, blood urea nitrogen, and urinalysis were not significantly different between placebo and treatment groups
To distinguish potential receptor-dependent and receptor-independent effects of melatonin, we employed Luzindole, a dual MT1/MT2 antagonist
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