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358 For ferroptosis, which represents a therapeutically actionable vulnerability, restoring iron-dependent lipid peroxidation is key
Lung Diseases Smoking tobacco causes oxidative damage to lung cells mainly due to the additives in most tobacco products
Results are more subtle but safer
J Biol Chem (2003) 278(19):171907
The cycle above utilizes key antioxidants such as glutathione (GSH) and ascorbate (AsA) and enzymes such as dehydroascorbate reductase (DHAR), glutathione reductase (GR), monodehydroascorbate reductase (MDHAR), and ascorbate peroxidase (APX)
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