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26 At the molecular level, senomorphics exert their effects primarily by modulating the signaling pathways that govern SASP production without inducing apoptosis in senescent cells

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Systemic inhibition of the SSP may induce potential toxicities and narrow the therapeutic window

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Schmidt-Sommerfeld E, Penn D, Sodha RJ, Prgler M, Novak M, Schneider H (1985)

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Helms, Eric PhD, CSCS2

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