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More serious but rarer side effects include pancreatitis (uncertain risk increase), gallbladder disease (increased risk with rapid weight loss), hypoglycemia when combined with other diabetes medications, and injection site reactions
The good news is that this is not inevitable
The research question Koren and his team are now trying to answer: Can combining the two do more than either one alone
Mechanistic investigations highlight that GLP-1 RAs have not just weight loss, but also anti-inflammatory and metabolic properties, suggesting their efficacy against several chronic conditions
Semaglutide GLP-1 works by mimicking the GLP-1 hormone , regulating appetite and food intake, promoting fullness, and reducing calorie consumption
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