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While these medications offer substantial metabolic and cardiovascular benefits, clinicians should remain vigilant, particularly when prescribing to older patients at risk of retinal disease

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Signalling pathways studied in preclinical models illustrative Melanocyte Stimulation & Pigmentation MC1R Agonism Melanotan II (MTII) activates MC1R on melanocytes, stimulating intracellular cAMP production that drives melanogenesis the synthesis of eumelanin (brown-black) pigment