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Studies in humans have also confirmed that consuming fat and sugar simultaneously promotes overeating (Hedrih, 2024), likely due to increased reward responses from separate neural gut-brain pathways activated by sugar and fat (McDougle et al., 2024)
This helps reduce GI side effects such as nausea, vomiting, constipation, and diarrhea
39 Therapy with semaglutide resulted in significant weight loss, an increase in 6MWT distance, improvement in quality of life (KCCQ-CSS), and a significant reduction in CRP
These concerted effects of FGF23 in the kidney result in reduced production of calcitriol, increased excretion of inactive 24,25-dihydroxycholecalciferol, and reduced levels of serum phosphate
The GI symptom rates nearly doubled when participants skipped the lower starting dose
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