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Start conservatively and adjust based on results

In both rat models of limbic epilepsy and human brain tissue obtained from individuals diagnosed with temporal lobe epilepsy, postmortem analyses have revealed extravasation of IgG and a significant loss of ZO-1 immunostaining, indicative of BBB compromise [77]

In terms of mechanism, two key pathways are mainly responsible for activating apoptosis: the intrinsic pathway (mitochondria-mediated pathway) and the extrinsic pathway (death receptor-mediated pathway) (101, 102)

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Glutamine is the most abundant amino acid in our body