Awad, A
Once these harmful substances stick to glutathione, the body can safely eliminate them
NatureMDPI Long term human safety, pharmacokinetics, optimal dose, systemic exposure and oncologic risk signals are undefined (absence of evidence, not evidence of safety)
Key Points Incomplete understanding of the pathogenesis of Parkinson disease (PD), lack of accurate animal models and validated biomarkers, and limitations in trial design impede the development of effective neuroprotective therapies for PD Novel transgenic animal models, adaptive and delayed-start trial designs, and identification of potential serum, cerebrospinal fluid and neuroimaging biomarkers are facilitating development and testing of effective disease-modifying therapies -Synuclein has a key role in the pathogenesis of PD
Emerging human data, including small pilot studies showing good tolerability (e.g., intravenous infusions up to 20 mg with no adverse effects) and subjective improvements in conditions like chronic knee pain, further support its promise