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Independent replication outside the Sikiric group exists but is limited
The IRR is upregulated in injured brain tissue following trauma, and its activation by ARA-290 reduced neuronal apoptosis, microglial-mediated neuroinflammation, and functional deficits in animal models
It is believed to be beneficial in managing these conditions by aiding in the reduction of inflammation and oxidative stress
METAOD005: A Phase IIb (randomized, double-blind, placebo-controlled) study to assess the efficacy (reduction in body weight), safety and tolerability of 12 weeks treatment with daily doses (1, 5, 10, 20 or 30 mg AOD9604) administered orally (capsules) in 300 healthy, clinically obese males, and females of non-child bearing potential, with a BMI 35 kg/m 2
99% confirmed via HPLC
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