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5-Amino-1MQ is a small-molecule competitive inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that catalyzes the methylation of nicotinamide using S-adenosyl methionine (SAM)
Key finding: AOD 9604 (0.1-10 mcg/kg) promoted cartilage repair with 52% defect filling versus 8% in controls
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Early work, including in the Journal of Medicinal Chemistry, has mapped these relationships to guide the design of next-generation NNMT inhibitors
This can create an issue for people with diabetes
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