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Over 70% of Americans are either overweight or have obesity, so a large percentage of the target population for addiction treatment already falls into the broad category of individuals for whom GLP-1s have well studied benefits for health and mortality
Vukojevic J, et al
Inhibition of cysteine-glutamate transporter protein system (e.g., Erastin) will deplete intracellular GSH, eventually resulting in the inactivation of GPx4 and the accumulation of lipid peroxidation, which can induce cell ferroptosis to a certain extent [75]
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