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GH and IGF-1 both play roles in tissue repair, collagen synthesis, and cellular regeneration

This dimeric interaction is vital to the outcome of Fc:FcRn binding, as asymmetrical removal of FcRn binding to one of the two sides of the Fc drastically reduces both cellular transport and the plasma half-life of IgG [56, 59, 60]

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Subsequent investigational work explored ghrelin-receptor agonists like ipamorelin for conditions such as postoperative ileus, but ipamorelin never reached an approved marketed indication