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doi:10.1016/j.tifs.2021.07.004 137

Supplementation with this antioxidant can help lighten the skin

For the body to resist these damages, it possesses a range of endogenous antioxidants, primarily enzymatic antioxidants (superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione S-transferase (GST), glutathione reductase (GR), thioredoxin reductase (TrxR), catalase (CAT), etc.), and nonenzymatic antioxidants (glutathione (GSH), bilirubin, ubiquinone, etc.) [11]

Middleton et al., 2022), but rather we have investigated a proof-of-concept to establish the feasibility of defining a NAM toolbox to be included within an NGRA approach for lung toxicity

Chronic oxidative stress is linked to a wide range of diseases, including: Cardiovascular disease : ROS damage endothelial cells lining blood vessels, promoting atherosclerosis and hypertension.[9] Neurodegenerative disorders : Oxidative damage to neurons is a key driver in conditions like Alzheimers, Parkinsons and ALS.[10] Diabetes and insulin resistance : Oxidative stress impairs insulin signaling and worsens glycemic control.[10] Cancer : DNA mutations caused by free radical damage may initiate or accelerate tumor development.[11] Autoimmune conditions : Oxidative stress can trigger inflammatory pathways, contributing to immune dysregulation.[9] Even outside of these conditions, oxidative stress contributes to fatigue, slower recovery, immune suppression and premature aging at the cellular level