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The first and rate-limiting step of GSH synthesis is catalyzed by glutamate-cysteine ligase, which is regulated by cysteine availability at the level of transcription and translation 6

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Janosik M, Kery V, Gaustadnes M, Maclean KMN, Kraus JP: Regulation of human cystathionine beta-synthase by S-adenosyl-L-methionine: Evidence for two catalytically active conformations involving an autoinhibitory domain in the C-terminal region

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doi: 10.3389/fgene.2023.1233669 17 de KrakerJWGershenzonJ