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Antioxidants & Redox Signaling, 23 (11), 985-997
Tirzepatide is no exception, and compounded versions may carry additional considerations compared to the FDA-approved product
After reconstitution, aliquot to minimize repeated freeze-thaw cycles
It is a coordination complex: a tripeptide ligand, glycyl-histidyl-lysine, bound to copper in the divalent state through the N-terminal amine, a deprotonated backbone amide nitrogen and the imidazole nitrogen of the histidine side chain
Capsules may serve as a convenient but underwhelming introduction to the peptide
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