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Additionally, alignment to the central helical Z -axis and a simple morph of the global basal and activated models show that the large conformational change is possible in the filament with fewer clashes when the CD moves in concert with the RDs (Supplementary Fig

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11 Mtodos de deteccin Mtodo de titulacin Procedimiento de anlisis: Pesar aproximadamente 0.1 g de la muestra secada hasta peso constante (precisin de 0.0001 g), aadir 20 mL de cido actico glacial y luego realizar una titulacin potenciomtrica con una solucin valorante estndar de cido perclrico (0.1 mol/L)