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This perspective has shifted substantially over the past 2 decades as accumulating evidence has demonstrated that both tissues secrete bioactive peptides that function as hormones, influencing glucose metabolism, energy expenditure, reproductive physiology, and aspects of aging

Fasting Glucose Why it matters: While A1c provides a longer-term picture, fasting glucose captures your blood sugar at a single point in time and can reveal patterns that A1c may miss particularly in people with certain hemoglobin variants that affect A1c accuracy

However, its efficacy is substantially compromised in patients with obesity caused by MC4R deficiency, a common monogenic form of obesity