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Carmody M, Waszczak C, Idnheimo N, Saarinen T, Kangasjrvi J (2016) ROS signalling in a destabilised world: a molecular understanding of climate change

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Incidence for hepatocellular carcinoma was significantly higher among NASH patients (0.8 vs 14.8), however no significant differences were noted for fibrosis progression (62.8 vs 115.7 ), cirrhosis (5.7 vs 10.8), and decompensation (2.4 vs 4.6)

Genetic variations can affect drug metabolism, leading to an induced risk of hepatotoxicity

Cagrilintide basically amplifies those natural effects, making them stronger and longer-lasting