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This is one of the most interesting and underused developments in rheumatology
Serious adverse events are rare at prescribed doses, though patients with personal or family history of medullary thyroid cancer or multiple endocrine neoplasia should discuss alternatives with their healthcare provider
Genetic factors, baseline metabolic health, and diet quality all influence response speed and magnitude
It was granted in June 1995 (Eng
That number is not just large in absolute terms, it is the largest weight-loss signal ever reported in a randomized Phase 3 trial of a GLP-1-class compound, and it arrived with additional secondary findings that reframe what "GLP-1 therapy" could eventually mean: a 75.8% reduction in osteoarthritis pain, a roughly 20% drop in LDL cholesterol, and a 72% reversal rate of prediabetes to normoglycemia in the affected subpopulation
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