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Centenarians have plasma MOTS-c levels resembling those of people decades younger, suggesting preserved mitochondrial signaling is a feature of exceptional aging
Severe constipation lasting more than a week despite fiber, hydration, and exercise interventions may require dose adjustment
Some patients may notice fatigue or mild headaches, and these too tend to resolve with time
Stress & substances: Manage stress and limit alcohol and smoking, which can accelerate cellular aging
However, GLP-1 delivery can be slow, sometimes taking up to two weeks, and the weight-loss program itself is very basic
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