Notably, oxidized glutathione (GSSG) increased in areas, including the caudate nucleus, highlighting region-specific redox imbalances
During dose escalation The transition from one dose to the next is when side effects are most intense
Patients should receive education on: Meticulous skin hygiene and moisturization Prompt treatment of minor wounds Recognition of early infection signs (erythema, warmth, fever) Immediate medical attention for suspected cellulitis Some patients with recurrent cellulitis (typically 3-4 episodes annually) may benefit from prophylactic antibiotics according to Infectious Diseases Society of America guidelines
The initial dose for many patients is 2.5 mg once weekly, which is often increased over time based on tolerance and treatment goals
The reduced availability of these medications, combined with their high cost, has led many patients to seek alternative ways to obtain them, including compounded medications that may not offer the same potency or safety profile as approved drugs