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The observation that the insulinotropic actions of GLP-1 are reduced in type 2 diabetes mellitus (T2DM) led to the development of incretin-based therapies GLP-1 receptor agonists and dipeptidyl peptidase 4 (DPP-4) inhibitors for the treatment of hyperglycaemia in these patients
Key considerations include: Under-dosing risks: Insufficient receptor engagement may yield minimal benefit
Further studies incorporating markers such as ezrin, along with assessments of both glutamate and GABA metabolism, will be interesting to determine whether these represent distinct pathological states or alternative expressions of astrocytic dysfunction under stress
Medication Timing and Dose Adjustment Injectable semaglutide (Ozempic, Wegovy) is administered once weekly, while oral semaglutide (Rybelsus) is taken daily
This rides the GLP-1 arm, so it is light at the bottom of the ladder and stronger higher up
US$ 28.00
US$ 23.63
US$ 23.70
