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The FDA-approved titration protocol for semaglutide involves weekly dose increases: 0.25 mg, then 0.5 mg, then 1.0 mg, then 1.7 mg, and finally 2.4 mg at maintenance
That compresses development and regulatory risk for the oral version relative to a truly novel mechanism
The 2.5 percentage point gap between male and female weight loss percentages is the smallest gender gap ever recorded in an obesity pharmacotherapy trial
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