lipedema tirzepatide Is a Game Changer For Super Fat Patients Like Me | by Shannon Ashley | Honestly Yours Puffy legs, heavy aches, rippled

In most cases, this wont last long and can be easily treated from home

Its baked into the very biology of how these systems interact

TRIUMPH-4 (Completed December 2025) Primary Endpoints: Weight loss (28.7% achieved) Knee osteoarthritis pain reduction (75.8% improvement) Secondary/Exploratory Endpoints (Liver): Liver enzymes (ALT, AST, GGT) Possibly liver imaging (ultrasound or MRI) in subset Not liver biopsies Expected Publication: 2026 (full results) What We'll Learn: Do liver enzymes normalize with 28.7% weight loss in larger population

Mittman BG, Le P, Payne JY, Ayers G, Rothberg MB

These findings highlight how obesity stigma can persist even when people pursue medically approved treatments