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In a single internally consistent radioligand series measuring inhibition of I-NDP-alpha-MSH binding to membranes from BHK570 cells stably expressing each human receptor, bremelanotide returned Ki values of 0.25 nM at MC4R, 6.4 nM at MC1R, 17 nM at MC5R and 53 nM at MC3R, corresponding to pKi 9.6, 8.2, 7.8 and 7.3 respectively

There were no differences between the groups with and without prior cholecystectomy ( p = 0.167, Table 3)

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References: Once-Monthly Maridebart Cafraglutide for the Treatment of Obesity A Phase 2 Trial

Inability to maintain adequate oral fluid intake due to these symptoms constitutes a medical concern requiring provider contact