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Randomized, placebo-controlled study of once-weekly exenatide in 44 non-diabetic, obese children ages 1018, which found a 2.3% decrease in BMI with exenatide compared with placebo
Additionally, expanding the investigation to non-diabetic and non-obese populations will be critical for determining the broader applicability of these findings
Common signs include persistent fatigue, low sex drive, difficulty building muscle, increased body fat, brain fog, and mood changes like irritability or depression
Individuals with a history of medullary thyroid carcinoma, MEN2, or pancreatitis are typically excluded from retatrutide trials as a class-based safety precaution
Alongside the medication, the protocol includes foundational support: Protein intake of 0.7-1g per pound of body weight to preserve lean mass Consistent sleep hygiene to support thyroid and cortisol regulation Breathwork practices to reduce systemic stress and support parasympathetic tone Moderate resistance training to build metabolically active tissue without triggering flares These aren't optional add-ons
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